Get Abnormal Embryogenesis: Cellular and Molecular Aspects PDF

By Patricia A. Martin-Deleon, Evelyn L. Shaver (auth.), T. V. N. Persaud (eds.)

ISBN-10: 9401166544

ISBN-13: 9789401166546

ISBN-10: 9401166560

ISBN-13: 9789401166560

The research of start defects has assumed an value even better now than long ago simply because mortality charges attributed to congenital anomalies have declined some distance lower than these for different motives of loss of life, corresponding to infectious and dietary ailments. it truly is envisioned that as many as 50% of all pregnancies terminate as miscarriages. within the majority of instances this can be the results of defective improvement. significant congenital malformations are present in at the least 2% of all liveborn babies, and 22% of all stillbirths and little one deaths are linked to serious congenital anomalies. Teratological reviews of an experimental nature are neither moral nor justifiable in people. various investigations were conducted in laboratory animals and different experimental types with a purpose to increase our knowing of irregular intrauterine improvement. In under 20 years the sphere of experimental teratology has complicated phenomenally. as a result of wide selection of knowledge that's now collecting, it has develop into attainable to acquire an perception into the reasons, mechanisms, and prevention of beginning defects. despite the fact that, significant paintings might be wanted earlier than those difficulties will be resolved. The comributions during this quantity contain a few of the more moderen and intriguing observations at the mobile and molecular features of developmental defects. it's not just a documentation of the most recent experimental paintings, however it additionally shows new and critical components for destiny research.

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Advances in Teratology, 4, pp. 62-93. (New York: Academic Press) 40. Brown, G. C. and Karunas, R. S. (1972). Relationship of congenital anomalies and maternal infection with selected enteroviruses. Am. J. • 95, 207 41. Heath, H. , Shear, H. , Imagawa, D. , Jones, M. H. and Adam, J. M. (1956). Tera- 43 ABNORMAL EMBRYOGENESIS: CELLULAR AND MOLECULAR ASPECTS 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. togenic effects of Herpes simplex, vaccinia, influenza-A (NWS) and distemper virus infections on early chick embryos.

Sister chromatid exchanges induced by mitomycin C: a new method of detecting DNA damage at chromosomal level. Mutat. , 28, 459 Kram, D. and Schneider, E. L. (1978). Reduced frequencies of mitomycin C induced sister chromatid exchanges in AKR mice. Hum. , 41, 45 Vogel, W. and Bauknecht, T. (1976). Differential chromatid staining by in vivo treatment as a mutagenicity test system. Nature, 260, 448 Solomon, E. and Bobrow, M. (1975). Sister chromatid exchange - a sensitive assay of agents damaging human chromosomes.

24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. malities in maternal and fetal tissues of magnesium- or zinc-deficient rats. Teratology, 12, 221 Skalko, R. G. and Packard, D. , Jr. (1974). The teratogenic response of the mouse embryo to 5-iododeoxyuridine. Experientia, 29, 198 Skalko, R. , Packard, D. , Schwendimann, R. N. and Raggio, J. F. (1971). The teratogenic response of mouse embryos to 5-bromodeoxyuridine. Teratology, 4, 87 Tamimura, T. (1968). Effects of Mitomycin C administered at various stages of pregnancy upon mouse fetuses.

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Abnormal Embryogenesis: Cellular and Molecular Aspects by Patricia A. Martin-Deleon, Evelyn L. Shaver (auth.), T. V. N. Persaud (eds.)

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