By Günter Obe, H.H. Evans, D. Frankenberg, M. Frankenberg-Schwager, E. Gebhart, W. Köhnlein, R.H. Nussbaum, D.G. Papworth, J.R.K. Savage, R.-D. Wegner
Applied genetic learn, genetic toxicology and mutation study examine the mutagenicity and cancerogenicity of chemical substances and different brokers. everlasting mutation in genes and chromosomes, may be triggered by means of a plethora of brokers, together with ionizing and nonionizing radiations, chemical substances, and viruses. one of the elements mentioned through Advances in Mutagenesis Research are (1) the knowledge of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate advent of mutagenic brokers into the environment.
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Extra resources for Advances in Mutagenesis Research
1980; Giaccia et al. 1985; Whitmore et al. 1989). In accordance with the view that little repair of relevant a-radiation-induced lesions occurs, variation in cell sensitivity to lethal effects at different cell cycle stages is much less in cells exposed to a-radiation or to radiation with particles of a similar LET,2 than to low-LET radiation (Raju et al. 1975; Sasaki 1984; Geard 1985). Repair-deficient strains which show hypersensitivity to the lethal effects of low-LET radiation show a response similar to the repair-efficient parental wildtype strains following exposure to a-radiation (Frankenberg et al.
H. Evans low-LET radiation (Blocher 1988; Cornforth 1990). The observation that the rejoining of a fraction of these breaks is not accompanied by a comparable increase in cell survival indicates that misrepaired and/or residual unrepaired breaks constitute the lethal lesions. In contrast to mammalian cells, repair of a-radiation-induced PLD does occur in S. cerevisiae (Reddy et al. 1976; Bertsche 1978), although the rate of repair is slower after a-radiation than after low-LET radiation (Reddy et al.
Mol BioI Rep 3:437-442 Martin-Bertram H, Hagen U (1979) Genomic integrity ofTI DNA aftery- and UV irradiation. Biochim Biophys Acta 561:312-323 Natarajan AT, Obe G (1984) Molecular mechanisms involved in the production of chromosomal aberrations. Chromosoma 90: 120-127 Petin VG (1979) Effect of gamma and alpha irradiation on survival of wild-type and sensitive mutants of yeast. Mutat Res 60:43-49 Reddy NMS, Anjaria KB, Subrahmanyam P (1982) Absence of a dose rate effect and recovery from subletbal damage in rad52 strain of diploid yeast Saccharomyces cerevisiae exposed to gamma rays.
Advances in Mutagenesis Research by Günter Obe, H.H. Evans, D. Frankenberg, M. Frankenberg-Schwager, E. Gebhart, W. Köhnlein, R.H. Nussbaum, D.G. Papworth, J.R.K. Savage, R.-D. Wegner