New PDF release: Alcohol and the Nervous System

By Edith V. Sullivan, Adolf Pfefferbaum

ISBN-10: 0444626190

ISBN-13: 9780444626196

Alcohol is the main common drug on the planet, but alcoholism continues to be a major dependancy affecting approximately 20 million american citizens. Our present knowing of alcohol's influence on mind constitution and similar practical harm is being revolutionized via genetic examine, uncomplicated neuroscience, mind imaging technological know-how, and systematic learn of cognitive, sensory, and motor talents. quantity one hundred twenty five of the instruction manual of scientific Neurology is a complete, in-depth treatise of reviews on alcohol and the mind protecting the elemental realizing of alcohol's impression at the important worried process, the prognosis and therapy of alcoholism, and prospect for restoration. The chapters inside might be of curiosity to medical neurologists, neuropsychologists, and researchers in all features and degrees of the neuroscience of alcohol and alcoholism.

  • The first concentrated reference particularly on alcohol and the brain
  • Details our present figuring out of the way alcohol affects the principal fearful system
  • Covers scientific and social impression of alcohol abuse problems and the biomedical outcomes of alcohol abuse
  • Includes part on neuroimaging of neurochemical markers and mind function

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Example text

Thus, a within-system neuroadaptation is a molecular or cellular change within a given reward circuit to accommodate overactivity of hedonic processing associated with addiction, resulting in a decrease in reward function. The emotional dysregulation associated with the withdrawal/negative affect stage also may involve between-system neuroadaptations in which neurochemical systems other than those involved in the positive rewarding effects of drugs of abuse are recruited or dysregulated by chronic activation of the reward system.

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Litten RZ, Allen JP (1991). Pharmacotherapies for alcoholism: promising agents and clinical issues. Alcohol Clin Exp Res 15: 620–633. Litten RZ, Fertig J, Mattson M et al. (2005). Development of medications for alcohol use disorders: recent advances and ongoing challenges. Expert Opin Emerg Drugs 10: 323–343. Litten RZ, Egli M, Heilig M et al. (2012). Medications development to treat alcohol dependence: a vision for the next decade. Addict Biol 17: 513–527. Lopez MF, Becker HC (2005). Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6 J mice.

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Alcohol and the Nervous System by Edith V. Sullivan, Adolf Pfefferbaum


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