Get Bioassay Methods in Natural Product Research and Drug PDF

By T. Elmqvist (auth.), Lars Bohlin, Jan G. Bruhn (eds.)

ISBN-10: 9401060193

ISBN-13: 9789401060196

ISBN-10: 9401148104

ISBN-13: 9789401148108

Bioassay tools in usual Product study and Drug Development comprises the court cases from the Phytochemical Society of Europe's very winning symposium in this subject, held August 24-27, 1997 in Uppsala, Sweden.
during this quantity, major educational and commercial scientists talk about novel equipment for assaying usual items to discover new structure-activity relationships. Of key significance during this strategy is the supply and reliability of particular bioassay tools, yet chapters additionally speak about chemical and organic range and the way to dereplicate common product extracts to extend potency in lead discovery.
Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory typical items are mentioned. quite a few business initiatives are awarded for the 1st time.
This quantity bridges the distance among educational and commercial examine and scientists, and may be required analyzing in drug businesses and schools of pharmacy, in addition to serving scientists in pharmacognosy, pharmacology, phytochemistry, normal items and drug discovery.

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Exp. Ther. 279: 645-651, 1996. B. : Specific inhibition of the reverse transcriptase of Human Immunodeficiency Virus Type 1 and the chimeric enzymes of Human Immunodeficiency Virus Type I and Type 2 by nonnucleoside inhibitors. Antimicrob. Agents Chemother. 37: 1037-1042, 1993. B. R: Kinetic analysis of inhibition of Human Immunodeficiency Virus Type-l reverse transcriptase by calanolide A. J. Pharmacol. Exp. Ther. 279: 652-661, 1996. M. R: The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia oValifolia and Clusia rosea.

Iwasa. • and Kubo. T. : are plants smart investors? Functional &01. in press. Verpoorte. R. van der Heijden. R.. and Moreno. H. (1997) Biosynthesis of terpenoid indole alkaloids in Catharanthus roseus. The Alkaloids. A. Cordell (Editor) Academic Press. San Diego. In press. Wijnsrna. R.. Verpoorte. R.. Mulder-Krieger. • and Baerheim Svendsen. A. (1984) Anthraquinones from callus cultures of Cinchona ledgeriana. Phytochemistry 23. 2307-2311 Wijnsma. R.. Go. A .. van Weerden. N .. Barkes. A .. Verpoorte.

Tetrahedron 51: 10653-10662,1995. M. R: The calanolides, novel HIV-inhibitory coumarins from the tropical rainforest tree Calophyllwn lanigerum. J. Med. Chem. 35: 2735-2742, 1992. B. R: Antiviral activity and mechanism of action of calanolide a against the Human STRATEGIES FOR SELECTION 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 35 Immunodeficiency Virus Type-l. J. Pharmacol. Exp. Ther. 279: 645-651, 1996. B. : Specific inhibition of the reverse transcriptase of Human Immunodeficiency Virus Type 1 and the chimeric enzymes of Human Immunodeficiency Virus Type I and Type 2 by nonnucleoside inhibitors.

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Bioassay Methods in Natural Product Research and Drug Development by T. Elmqvist (auth.), Lars Bohlin, Jan G. Bruhn (eds.)


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