Read e-book online Bipolar Depression: A Comprehensive Guide PDF

By Rif S. El-Mallakh, S. Nassir Ghaemi

ISBN-10: 1585621714

ISBN-13: 9781585621712

ISBN-10: 1585626511

ISBN-13: 9781585626519

Even supposing melancholy is the most typical presentation of bipolar disease, right prognosis normally calls for a historical past of mania and therefore provides an impressive problem. This ebook presents clinicians with the mandatory counsel to differentiate this ailment and pursue a suitable healing direction. It brings jointly a staff of medical investigators who supply state-of-the-art examine at the subject and deal with the main serious issues relating to its remedy. Bipolar melancholy first introduces a hierarchical version for prognosis to permit the clinician to differentiate among bipolar and unipolar melancholy, addressing difficulties of misdiagnosis and overdiagnosis in addition to differentiating attention-deficit/hyperactivity sickness (ADHD) and bipolar illness. Early chapters evaluation the neurobiology and genetics of this hugely heritable , proposing stories of neurotransmitter functionality and mind imaging experiences and documenting the susceptibility of particular chromosomes as loci for bipolar ailment. different chapters tackle the actual problems with bipolar melancholy in young ones, for whom a analysis is mainly tricky, and suicide, concentrating on the necessity for review in the course of either acute and upkeep remedy with interventions applicable to a patient's signs and heritage. Bipolar melancholy deals reviews of particular remedy ways: -Lithium and antiepileptic medications: that includes a assessment of the newest study at the use of lithium, within which greater doses are proven to be potent, plus assurance of lamotrigine, valproic acid, carbamazepine, oxcarbazepine, and topiramate. -Antidepressants: delivering new views on a fancy box, together with a dialogue of the randomized medical trial literature and observational stories on their use, and bringing up cautions relating to unwanted effects. -Antipsychotics: comparing the variation among first- and second-generation medicines and discussing their function in controlling acute depressions. -Novel ways to therapy: together with using ordinary neuroleptics, electroconvulsive remedy, transcranial magnetic stimulation, vagus nerve stimulation, ketogenic vitamin, omega-3 fatty acids, myo-inositol, and dopamine agonists. -Psychological interventions: concentrating on the inclusion of cognitive-behavioral treatment or interpersonal social rhythm remedy for nonmelancholic depressions in sufferers who had formerly got psychoeducation. regardless of the earlier decade's advances in perform and learn, there continues to be a lot room for development in realizing and treating bipolar melancholy. This e-book blazes a path towards that objective, establishing new doorways in spotting transformations among bipolar and unipolar varieties of melancholy whereas supplying either researchers and clinicians key insights into this troubling ailment.

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Additional info for Bipolar Depression: A Comprehensive Guide

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Note. Four models for specificity of relationships between depressive episodes and bipolar disorder. Abbreviations: B=bipolar, D=depression, M =mania, U=unipolar. imposed on either bipolar or unipolar disorder, or 4) so-called bipolar and unipolar disorders could be forms of the same illness. We will discuss the biology of bipolar depression in the context of these possibilities. For simplicity, we will refer to nonbipolar, recurrent, primary depressions as unipolar depressions. We define biology broadly to include genetic and physiological characteristics, and we will discuss clinical characteristics that can be taken as evidence for underlying biological mechanisms.

Philadelphia, PA, 2002 El-Mallakh RS, Karippot A: Antidepressant-associated chronic irritable dysphoria (acid) in bipolar disorder: a case series. J Affect Disord 84:267–272, 2005 Faedda GL, Baldessarini RJ, Glovinsky IP, et al: Pediatric bipolar disorder: phenomenology and course of illness. Bipolar Disord 6:305–313, 2004a Faedda GL, Baldessarini RJ, Glovinsky IP, et al: Treatment-emergent mania in pediatric bipolar disorder: a retrospective case review. J Affect Disord 82:149–158, 2004b Frankenburg FR, Zanarini MC: Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: a double-blind placebo-controlled pilot study.

2004). Hippocampal volume was reported to be decreased overall in unipolar, but not bipolar, depression (Geuze et al. 2004). In fact, increased right hippocampal volume was reported to correlate with poor cognitive function in bipolar depressed subjects (Ali et al. 2000). Signal intensity in the corpus callosum was reduced in subjects with bipolar disorder compared with unipolar disorder or controls (Brambilla et al. 2004), which is consistent with neuropsychological reports of deficits in interhemispheric switching (Pettigrew and Miller 1998).

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Bipolar Depression: A Comprehensive Guide by Rif S. El-Mallakh, S. Nassir Ghaemi


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